Agrosciences Services
by Tentamus

Tentamus Agro­sciences Group labo­ra­to­ries are recog­nized part­ners of the world’s leading agro­chem­ical compa­nies and have the most advanced analyt­ical equip­ment and facil­i­ties to meet our customers’ needs indi­vid­u­ally and efficiently.

Our agro­science labo­ra­to­ries are inspected and accred­ited by EPA, GLP and GEP compli­ance agen­cies in the US, Europe, Greater China and Israel.

We perform our studies for regu­la­tory require­ments of US, Euro­pean agen­cies, JMAFF, OPPTS, PMRA, WHO/FAO and follow a variety of inter­na­tional guidelines.

Our services include

Plant & Animal Metabolism

  • 14C‑licensed & AAALAC-accred­ited Animal Facility for in-Life Phase
  • Green­houses & Outdoor Facil­i­ties with 14C-License
  • Confined & Field Rota­tional Crops
  • Bio-Concen­tra­tion/ ‑Accu­mu­la­tion in Fish
  • Metabo­lite Identification
  • Capil­lary Elec­trophoresis-MS for Charged & Polar Metabolites

Envi­ron­mental Fate & Biodegradation

  • Biodegra­da­tion in Variety of Matrices
  • Field Dissi­pa­tion
  • Hydrol­ysis
  • Metab­o­lism
  • Mobility
  • Non-Guide­line Studies with Unique
  • Adap­ta­tion
  • Photo degra­da­tion

Method Devel­op­ment & Validation

  • 5‑Batch Analyses
  • Active Ingre­dient, Formu­lated Product
  • Certi­fi­ca­tion of Analysis
  • Devel­op­ment and Vali­da­tion of Single & Multi-Residue Analysis Methods
  • Enforce­ment Methods, Radio-Validation
  • Screening: Purity & Impu­rity Profile of the Active Substance

Phys­ical & Chem­ical Characterization

  • Chem­ical & Phys­ical Compat­i­bility and Miscibility
  • Devel­op­ment & Vali­da­tion of Methods for Tech­nical Grade & Formu­lated Products
  • Effec­tive­ness of Cleaning Procedures
  • Phys­ical & Chem­ical Analysis of Tech­nical Grade & Formu­lated Prod­ucts (EC Methods, CIPAC Hand­book Series, OECD & OPPTS Series)
  • Risk Studies for Trans­port & Storage
  • Stability Studies

Magni­tude of Residues

  • DCS, Processing, Soil Dissi­pa­tion & Crop Rota­tion Studies
  • Live­stock Feeding Studies at our Animal Facility
  • MOR Studies: In-Life Coor­di­na­tion, Analyt­ical in-House
  • Residue Studies & Field Trials
  • Storage Stability of Residues

Addi­tional Capabilities

  • Bio Pesti­cides: Active Compounds Sepa­ra­tion & Iden­ti­fi­ca­tion, Trials, Tech­nical Support & Analyt­ical Dossier
  • Bios­tim­u­lant Trials
  • Effi­cacy & Crop Safety Studies
  • Marketing & Demon­stra­tion Projects
  • Regu­la­tory Strategy & Risk Modeling/​Miti­ga­tion
  • Taint Testing
  • Vari­etal Eval­u­a­tion & Breeding Management

Plant and Animal Metab­o­lism Studies

The use of crop protec­tion prod­ucts in agri­cul­ture can result in residues remaining in the corre­sponding plant and animal foods. Using plant and animal metab­o­lism studies, our labo­ra­to­ries inves­ti­gate the uptake and metab­o­lism of agro­chem­i­cals in farm animals and plants.State-of-the-art analyt­ical methods and 14C labeling enable Tentamus Agro­sciences labo­ra­to­ries to iden­tify metabolites.

Regu­la­tion (EU) 396/2005 sets maximum residue levels of pesti­cides for plant and animal based products.

Envi­ron­mental Fate & Degradation

Because they are anthro­pogenic substances, the fate of agro­chem­i­cals in the envi­ron­ment begins with their appli­ca­tion to agri­cul­tural fields. The fate of substances in the envi­ron­ment is influ­enced by chem­ical, phys­ical, biolog­ical, and hydrom­e­te­o­ro­log­ical processes in soil, water, and air.

Incom­plete degra­da­tion of pesti­cides can lead to the forma­tion of toxic trans­for­ma­tion prod­ucts (TPs). Envi­ron­mental Fate (eFate) studies provide an oppor­tu­nity to inves­ti­gate the impact of agro­chem­i­cals on the envi­ron­ment (plants, water, soil, etc.).

Tentamus Group’s special­ized labo­ra­to­ries can perform eFate studies for you including hydrol­ysis, field dissi­pa­tion, mobility, photodegra­da­tion as well as biodegra­da­tion of various matrices and addi­tion­ally offer studies outside the guidelines.

Method Devel­op­ment and Validation

New methods need to be devel­oped and vali­dated espe­cially for new or special prod­ucts, research projects or regu­la­tory require­ments. The Tentamus Group labo­ra­to­ries can support you in precisely these areas, offering method devel­op­ment and vali­da­tion for agri­cul­tural biotech­nology, the chem­ical industry, and food and feed additives.

For regu­la­tory method vali­da­tions in accor­dance with GLP (Good Labo­ra­tory Prac­tice), including inde­pen­dent labo­ra­tory vali­da­tions (ILVs), work can be performed to meet applic­able requirements.

Phys­ical & Chem­ical Characterization

For regis­tra­tion and approval of chem­ical substances for agri­cul­ture, it is neces­sary to analyze and char­ac­terize these substances phys­i­cally and chemically.

For this purpose, the agri­cul­tural science team of the Tentamus Group has a number of methods at its disposal, the results of which are in turn eval­u­ated and inter­preted by our expe­ri­enced special­ists. New methods can also be devel­oped and vali­dated, and studies conducted. Studies include risk studies for storage and trans­port of chem­ical prod­ucts as well as stability studies.

Char­ac­ter­i­za­tion and analysis of Residues (labo­ra­tory, field studies)

Before crop protec­tion prod­ucts are regis­tered and approved for the market, they require thor­ough testing and eval­u­a­tion by appro­priate accred­ited labo­ra­to­ries and, ulti­mately, regu­la­tory agen­cies. In order to ensure the safety of plant food and feed, no residues or only residues in spec­i­fied maximum levels may be detected.

With the help of various residue and field studies, the labo­ra­to­ries of the Tentamus Group can advise you on the level of possible residues of your crop protec­tion prod­ucts in the food and feed and develop appro­priate solu­tions together with you.

Humidome Studies

To deter­mine the volatility of an active ingre­dient in a partic­ular formu­la­tion, our labo­ra­to­ries can perform humidome studies in a controlled test envi­ron­ment (gener­ally within 24-hours). These can be performed both qual­i­ta­tively and quan­ti­ta­tively and offer tremen­dous cost and time savings compared to expen­sive flux studies. They are repeat­able and can test multiple formu­la­tions in a short period of time very effi­ciently to iden­tify the ideal formulation.

The U.S. EPA has required compa­nies marketing dicamba formu­la­tions to use humidome setups to eval­uate the effects of certain para­me­ters on the secondary move­ment of dicamba.

In controlled exper­i­mental envi­ron­ments provided by humidomes, the effect of temper­a­ture, rela­tive humidity, spray solu­tion pH, and a variety of tank mix part­ners on dicamba volatiliza­tion can be studied. As weed resis­tance to Round-UP increases world­wide, agro­chem­ical compa­nies have begun to incor­po­rate dicamba into their formu­la­tions to prevent further weed resis­tance devel­op­ment. As dicamba is volatile by nature, it has created new chal­lenges for growers who must deal with poten­tial damage to neigh­boring crops. Dicamba manu­fac­turers have been forced to develop new formu­la­tions in which the volatility of dicamba is minimized.

In support of humidome studies, our Tentamus Agro­sciences labo­ra­to­ries can also advise and provide analyt­ical support for the devel­op­ment of new agri­cul­tural prod­ucts or improve­ment of a marketed agri­cul­tural product.

GLP studies

To deter­mine the fate of residues in crops, animal prod­ucts, soil and water from crop protec­tion prod­ucts, we conduct studies according to Good Labo­ra­tory Prac­tice (GLP) guide­lines. Single and multi-methods can be devel­oped and validated.

In addi­tion, our agro­science labo­ra­to­ries can deter­mine and eval­uate the storage stability of residues in various types of mate­rials and samples.

Biopes­ti­cides

The impor­tance of biolog­ical pesti­cides has grown signif­i­cantly in recent years. These include micro­bials (fungi, bacteria, viruses, protozoa, algae), pheromones, semi-chem­i­cals, plant extracts, and insects and nematodes.

Here, too, you can benefit from Tentamus Agro­sciences Services. We provide regu­la­tory and analyt­ical support (5‑batch analysis, residue studies, phys­ical and chem­ical char­ac­ter­i­za­tion). We are happy to help you iden­tify suit­able proce­dures for your biopes­ti­cides and also to prepare the neces­sary dossiers.

Agrosciences Services
by Industry

Agri­cul­ture

Crop protec­tion prod­ucts, such as pesti­cides, herbi­cides or fungi­cides are mainly used in agri­cul­ture. The aim is to protect both neigh­boring natural habi­tats (soils, plants, water bodies) and the treated fields them­selves. To ensure that agri­cul­tural prod­ucts work only as intended – that is, to promote the growth of healthy plants and keep pests and weeds at bay – the Tentamus agro­science labo­ra­to­ries offer the following services to farms:

  • Soil Dissi­pa­tion & Crop Rota­tion Studies
  • Envi­ron­mental Fate – Biodegra­da­tion of products
  • Risk studies for trans­port & storage
  • Stability studies
  • Residue studies & field trials
  • Storage stability of residues
  • Effi­cacy & plant protec­tion studies
  • Variety eval­u­a­tion & breeding
  • Spoilage testing

Animal breeding and live­stock manage­ment are also part of agri­cul­ture. To track animal meta­bolic processes and ensure animal health, our labo­ra­to­ries can also offer you the following analyt­ical services:

  • 14C‑licensed & AAALAC-accred­ited animal facility for in-life phase
  • Metabo­lite identification
  • Capil­lary elec­trophoresis MS for charged & polar metabolites
  • Feeding studies in our animal facility
  • Residue content studies: in-life coor­di­na­tion, in-house analytics

Food Produc­tion Companies

The use of crop protec­tion prod­ucts not only affects fields and the envi­ron­ment, but also has an impact on the food that emerges from agri­cul­ture. The Tentamus Group there­fore places partic­ular emphasis on taking a holistic view of food produc­tion and offers food manu­fac­turers a valu­able total package. In our labo­ra­to­ries, we not only examine the crop protec­tion prod­ucts as such, but also the food on its way from the field to the plate.

The Tentamus Agro­sciences labo­ra­to­ries are equipped with state-of-the-art equip­ment for residue analysis and are thus able to quickly and effi­ciently provide results on residues remaining in food and advise you on appro­priate measures in case of exces­sive exposure.

Seed/​Plant Supplier

Planting high-quality seed is the foun­da­tion for a high-yielding crop. To ensure this, our labo­ra­to­ries offer a range of labo­ra­tory analyses and studies.

Our services for seed and crop suppliers include:

  • Limited & open field rota­tion crops
  • Residue studies & field trials
  • Major and minor plant metab­o­lism studies
  • Limited accu­mu­la­tion studies on rota­tion crops
  • Radio vali­da­tion
  • Metab­o­lism study with non-radi­o­la­beled new active ingredients

In addi­tion, 14C licensed green­houses & outdoor facil­i­ties are avail­able to our laboratories.

Approval of
Agrochemicals

Only approved crop protec­tion prod­ucts may be placed on the market and used. Both approval and use are governed by EU legis­la­tion. In order to use a partic­ular active ingre­dient, it must also be approved by the Euro­pean Commission.

The placing of crop protec­tion prod­ucts on the market is regu­lated by Regu­la­tion (EC) No. 1107/2009. The EU member states each eval­uate and approve crop protec­tion prod­ucts at the national level.

In Germany, the Federal Office of Consumer Protec­tion and Food Safety (BVL) handles the approval of a crop protec­tion product. In the U.S., the approval of pesti­cides and crop protec­tion prod­ucts is regu­lated by the Federal Insec­ti­cide, Fungi­cide, and Roden­ti­cide Act (FIFRA) and the Federal Food, Drug and Cosmetic Act (FFDCA).

Tentamus Group’s agro­science labo­ra­to­ries, through their expe­ri­enced and qual­i­fied team, have the regu­la­tory and scien­tific exper­tise to assist you with the marketing of your pesti­cide prod­ucts. In addi­tion to our consulting services, we offer the following services:

  • Marketability testing
  • Phys­ical and chem­ical characterization
  • Risk studies for trans­port and storage
  • Stability studies
  • Residue studies for the fate of residues in soil, water, food and feed
  • Envi­ron­mental Fate
  • Plant and animal metab­o­lism studies
  • Method devel­op­ment and vali­da­tion (single & multi-residue analyt­ical methods, enforce­ment methods, radio-validation)
  • 5‑batch analyses
  • Active substance analyses, analyses for formu­lated products
  • Certi­fi­ca­tion of analyses
  • Screening: purity & impu­rity profile of the active substance

The approval of a crop protec­tion product is limited (usually 10 years). In order for the product to continue to be used and remain on the market, it must be reassessed and eval­u­ated. Further­more, the EU Commis­sion can also initiate unsched­uled inspec­tions if there is a corre­sponding reason.

Tentamus Group
Your Partner for

Agrosciences Studies

With Tentamus Agro­sciences as your partner you get quality and exper­tise world­wide from one source. Your advan­tages are clear – with Tentamus Agro­sciences you get:

  • A recog­nized partner of top agro­chem­ical companies
  • A team with more than 20 years of experience
  • State-of-the-art analyt­ical equipment
  • Solu­tions indi­vid­u­ally tailored to your products
  • The possi­bility of method devel­op­ment and validation
  • Studies & analytics from a single source
  • Peer review process for quality manage­ment and quality assurance

Spectrum of Methods
of Tentamus Agrosciences

The labo­ra­to­ries of Tentamus Group in the field of agro­sciences have a wide range of modern analyt­ical equip­ment at their disposal:

  • C with MS, MS/MS, Q‑TOF, DAD, UV, ELSD and fluo­ri­metric detectors
  • Ion chro­mato­graph with conduc­to­metric detector
  • GC equipped with MS, MS/MS, ECD, NPD and FID detec­tors and head­space autosampler
  • ICP-OES for the analysis of metals
  • Complete equip­ment for micro­bi­o­log­ical analysis
  • PCR, Real-Time qPC and PCR-Ther­mo­cy­cler – Elec­trophoresis
  • ELISA
  • Southern Blot Analysis (P32) and Western Blot Analysis

Our labo­ra­to­ries are also fully equipped for chem­ical and phys­ical char­ac­ter­i­za­tion of tech­nical and formu­lated products.

Adapted to our customers’ require­ments, our labo­ra­to­ries can also develop and vali­date new methods tailored to your product.

Overview of Analytical
Laboratories for Agrosciences Services of the Tentamus Group

The following labo­ra­to­ries of the Tentamus Group offer Agro­sciences Services:

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